Journal: bioRxiv
Article Title: Collagen targeting IL-12 combined with Doxorubicin enhances the anti-tumor effect against osteosarcoma
doi: 10.64898/2026.05.07.723520
Figure Lengend Snippet: We inoculated mice with 3 × 10 6 BVM03O OS cells subcutaneously on the back skin and the mice were treated with PBS (i.v., n = 5), 416.6 pmol of CBD–IL-12 (i.v., n = 5), and 416.6 pmol of CBD–IL-12 + 2 mg/kg of Dox (i.v., n = 5) on day 35. Dox was additionally injected 3 and 6 days post initial treatment. Average tumor growth curve (a), individual tumor curves (b), and survival curves (c) are shown. We inoculated mice with 5 × 10 6 K7M2 OS cells subcutaneously on the back skin and the mice were treated with PBS (i.v., n = 4) and 416.6 pmol of CBD-IL-12 + 2 mg/kg of Dox (i.v., n = 3) once the tumor volume reaches 50 mm 3 . Dox was additionally injected on day 3 and day 6. Average tumor curve (d), individual tumor curves (e), and survival curves (f) are shown. The results are expressed as mean ± S.E.M. Log-rank test was used for (c) and (f) in the statistical analysis. *P < 0.05, **P < 0.01. N.S., not significant; PBS, phosphate-buffered saline.
Article Snippet: K7M2 cells (CRL-2836) were purchased from ATCC.
Techniques: Injection, Saline